A comparative study on the neurotoxicity of n-pentane, n-hexane, and n-heptane in the rat.
نویسندگان
چکیده
The neurotoxicity of n-pentane, n-hexane, and n-heptane have been studied in Wistar strain male rats after exposure to 3000 ppm of n-pentane, n-hexane, or n-heptane for 12 hours a day for 16 weeks. The nerve conduction velocity and the distal latency were measured before the beginning of the exposure and after exposure for four, eight, 12, and 16 weeks. The experiment showed that n-hexane disturbed the conduction velocity of the motor nerve and the mixed nerve and prolonged the distal latency in the rat's tail, but that n-pentane and n-heptane did not. The light and electron microscopic examination showed that the peripheral nerve, the neuromuscular junction, and the muscle fibre of the rats exposed to n-hexane were severely impaired, but those of the rats exposed to n-pentane or n-heptane showed no particular changes even after 16 weeks of exposure. These results show that n-hexane is far more toxic to the peripheral nerve of the rat than n-pentane or n-heptane. It is necessary to study the neurotoxicity of other petroleum hydrocarbons, since some reports suggest that petroleum solvents might possibly contain neurotoxic hydrocarbons other than n-hexane.
منابع مشابه
Conversion of N-Heptane on Pt/Al2O3 Catalyst
Hydrogenation reaction with n-heptane on Pt/Al2O3 catalyst was investigated under the steady state condition in a fixed bed reactor. The catalyst was prepared under a variety of conditions, but the one chosen was non-acidic that is not considered a hydrocracking catalyst. The main objective was to vary the selectivity of n-heptane as a function of reaction variables es...
متن کاملA Novel Technique for Determination of the Onset of Alkane Induced Asphaltene Precipitation Using Accurate Density Measurements
Onset of asphaltene precipitation is the key parameter in dealing with asphaltene problems because it is the starting point of the asphaltene separation from the solution. In this study, a new technique is provided based on the experimental observations for the determination of the onset of asphaltene precipitation using accurate density measurements of the crude oils upon titration with precip...
متن کاملبررسی استخراج آسفالتین از باقیمانده های سنگین نفتی با استفاده از حلالهای مایع
In the 1970s, regulations in some countries forced users of heavy residue to limit pollutant emissions at industrial sites, also forced producers to upgrade their heavy products for export and domestic use. For this reason Iran as a producer, exporter and consumer has to develop new upgrading processes. The most common processes for upgrading heavy oil are catalytic processes, but existence of ...
متن کاملMonte Carlo Simulation of Methanol Diffusion in Critical Media
The diffusion behavior of methanol in different critical media (n-pentane, n-hexane, n-heptane and acetone) was investigated by the Monte Carlo (MC) method. From the simulation results, the diffusion constant of methanol molecule in the critical n-hexane is much larger than those in n-pentane, n-heptane and acetone. By analyzing the microscopic configurations of the critical mixtures, it is fou...
متن کاملHydroisomerization of n-Pentane over Pt/Mordenite Catalyst: Effect of Feed Composition and Process Conditions
The hydroisomerization of pure n-pentane over H-mordenite supported Pt-catalyst was investigated in a fixed bed reactor by changing reaction parameters such as temperature, pressure, and WHSV, as well as the H2/HC ratio. The maximum yield of isopentane over Pt/mordenite catalyst was achieved at 220 °C and a relatively low reaction pressure. To address the effect of feed composition on the catal...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- British journal of industrial medicine
دوره 37 3 شماره
صفحات -
تاریخ انتشار 1980